This research aimed to evaluate the potential therapeutic effects of whole-body hyperthermia (WBH) in combination with cognitive behavioral therapy (CBT) for adults with major depressive disorder (MDD). Major depressive disorder affects over 300 million people globally and is a leading cause of disability, with current treatments often falling short in terms of effectiveness and causing undesirable side effects. The study conducted a single-arm feasibility trial, involving up to 8 weekly or 4 bi-weekly WBH sessions alongside 8 weekly CBT sessions, to assess the feasibility and efficacy of this combined treatment. The trial sought to explore the role of WBH as a complementary treatment for MDD, aiming to optimize treatment protocols and better understand the potential of integrating mind-body therapies for mood disorders.
The researchers hypothesized that WBH, a form of therapeutic heat exposure, could have a beneficial impact on depression, potentially by inducing physiological changes that promote improved mood regulation. Previous studies suggest that hyperthermic treatments like saunas can have mood-enhancing effects by reducing stress and inflammation, while CBT addresses the cognitive aspects of depression. By combining these therapies, the study aimed to determine whether the synergy between WBH and CBT could offer a more effective, well-tolerated treatment for MDD. Though this was a pilot study, the results indicated promise in integrating these therapies to improve mood disorders, offering a potential alternative for patients with depression who do not respond well to traditional pharmacological treatments. The study was conducted by researchers exploring the role of integrated mind-body approaches in treating depression.
