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The effectiveness and safety of topical PhotoActif phosphatidylcholine-based anti-cellulite gel and LED (red and near-infrared) light on Grade II-III thigh cellulite: a randomized, double-blinded study

In the study “The effectiveness and safety of topical PhotoActif phosphatidylcholine-based anti-cellulite gel and LED (red and near-infrared) light on Grade II-III thigh cellulite,” researchers Gordon H. Sasaki and colleagues aimed to assess the effectiveness of a combination treatment for reducing thigh cellulite. The study involved nine female volunteers with Grade II-III cellulite who used a phosphatidylcholine-based anti-cellulite gel combined with red (660 nm) and near-infrared (950 nm) LED light therapy. The participants applied the active gel twice daily to one thigh, while using a placebo gel on the other thigh. They also received 15-minute LED treatments twice a week for three months. The study tracked a variety of clinical measures, including photography, body measurements, and ultrasound imaging to assess the effects on skin appearance and structure.

The results showed that the combined treatment of the anti-cellulite gel and LED therapy significantly improved the appearance of cellulite in most participants. After three months, eight of the nine thighs treated with the active gel and LED therapy showed a reduction in cellulite grade. Ultrasound imaging revealed a significant reduction in subcutaneous fat protrusion and improved skin texture. While most participants experienced only mild side effects, such as temporary redness and swelling, the effects were mostly positive. However, the benefits were not entirely permanent, as five of the thighs reverted to their original cellulite grade after 18 months, suggesting that maintenance treatments might be necessary. This study highlights the potential of combining red light therapy with topical treatments to improve skin health and reduce cellulite.

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